(August 21, 2006) – Agent Mahone takes charge of the pursuit as the fugitives flee through Illinois.

– Michael's escape window closes; he must fight Whistler to the death.

" (S4E18) , marking a low point in the conspiracy-heavy fourth season.

"Eagles & Angels" – The team infiltrates a police benefit to copy the next card.

The debut season introduces structural engineer Michael Scofield as he deliberately enters Fox River State Penitentiary to save his brother Lincoln from death row.

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The first season introduces Michael Scofield's master plan: a full map of Fox River hidden inside an elaborate body tattoo. This 22-episode arc focuses entirely on the preparation and execution of the prison break, while introducing the shadowy political conspiracy known as "The Company."

Michael finds himself trapped in a brutal Panamanian prison where there are no guards inside, only inmates.

(May 1, 2009) – Michael tries to intercept his mother at an energy conference before she triggers an international crisis.

"The Old Head" – Michael tries to recruit Westmoreland, rumored to be D.B. Cooper.

Following their escape, the Fox River Eight are on the run across the country, pursued by Federal Agent Alexander Mahone, who is as intelligent as Michael. First Down Subdivision Rendezvous Bolshoi Booze Disconnect The Killing Box The Message Sweet Caroline Fin del Camino

| No. | Title | Original Air Date | | :--- | :--- | :--- | | 23 | Manhunt | August 21, 2006 | | 24 | Otis | August 28, 2006 | | 25 | Scan | September 4, 2006 | | 26 | First Down | September 11, 2006 | | 27 | Map 1213 | September 18, 2006 | | 28 | Subdivision | September 25, 2006 | | 29 | Buried | October 2, 2006 | | 30 | Dead Fall | October 23, 2006 | | 31 | Unearthed | October 30, 2006 | | 32 | Rendezvous | November 6, 2006 | | 33 | Bolshoi Booze | November 13, 2006 | | 34 | Disconnect | November 20, 2006 | | 35 | The Killing Box | November 27, 2006 | | 36 | John Doe | January 22, 2007 | | 37 | The Message | January 29, 2007 | | 38 | Chicago | February 5, 2007 | | 39 | Bad Blood | February 19, 2007 | | 40 | Wash | February 26, 2007 | | 41 | Sweet Caroline | March 5, 2007 | | 42 | Panama | March 19, 2007 | | 43 | Fin Del Camino | March 26, 2007 | | 44 | Sona | April 2, 2007 |

Prison Break, a popular American television series, aired from 2005 to 2009 and was revived in 2017. The show follows the story of two brothers, Michael Scofield (played by Wentworth Miller) and Lincoln Burrows (played by Dominic Purcell), as they navigate a complex web of crime, corruption, and redemption. With its gripping storyline, memorable characters, and intense plot twists, Prison Break became a fan favorite worldwide.

(April 24, 2009) – Michael and Lincoln square off on opposite sides of the hunt for Scylla in Miami.